The effects of Alzheimer's disease related striatal pathologic changes on the fractional amplitude of low-frequency fluctuations. Issue 16 (9th December 2020)

• Record Type: Journal Article
• Authors: Cakir, Yuksel
• Is Part Of: Computer methods in biomechanics and biomedical engineering. Volume 23:Issue 16(2020)
• Page Start: 1347
• Page End: 1359
• Publication Date: 2020-12-09
• Subjects: Izikhevich neuron model -- hemodynamic model -- striatum -- computational modeling -- fALFF -- bold signal; Biomechanics -- Data processing -- Periodicals; Biomedical engineering -- Periodicals; Biomechanics -- Periodicals; Biomedical Engineering -- methods -- Periodicals; Computing Methodologies -- Periodicals; 612.7
• DOI: 10.1080/10255842.2020.1801653
• Languages: English
• ISSNs: 1025-5842

Abstract

Abstract: This paper aims to correlate Alzheimer's disease (AD) related striatal pathologic changes with the fractional amplitude of low-frequency fluctuations (fALLF) in the blood oxygenation level-dependent (BOLD) signal in the resting state functional Magnetic Resonance Imaging (rs-fMRI). A dopamine modulated Izikhevich neuron model based network of striatum region is constructed. Balloon–Windkessel hemodynamic model is used to obtain BOLD signals. fALFF differences between two frequency bands (slow-5:0.01–0.027 Hz; slow-4:0.027–0.073 Hz) are investigated in the case of dopamine depletion, decrease in the synaptic connectivity and the input from cortical and thalamic region, assumed that they are the degenerations occurring in AD.