Lyciyunin, a new dimer of feruloyltyramine and five bioactive tyramines from the root of Lycium yunnanense Kuang. Issue 3 (1st February 2021)

• Record Type: Journal Article
• Authors: Xia, Zhao; Xu, Tian-qi; Xu, Wei; Zhang, Hai-xin; Liang, Qiu-ping; Zhou, Guang-xiong
• Is Part Of: Natural product research. Volume 35:Issue 3(2021)
• Page Start: 447
• Page End: 454
• Publication Date: 2021-02-01
• Subjects: Lycium yunnanense Kuang -- Lyciyunin -- feruloyltyramine -- ECD calculations -- antioxidant activity -- anti-inflammatory activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2019.1636375
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Lyciyunin, a new dimer of feruloyltyramine (1 ), together with five known tyramines (2–6 ), was isolated from the water-soluble fraction of an EtOH extract of the root of L. yunnanense . Based on HR-TOF-MS, NMR spectral data and quantum chemistry ECD calculations, the structure of this new compound was determined, including its absolute configuration. Compounds (1–6 ) were tested for their antioxidant activity using in vitro DPPH radical scavenging assay, and 1–6 showed the moderate antioxidant activities with IC50 values of 12.44 ± 0.39, 21.29 ± 0.75, 24.44 ± 1.63, 21.15 ± 0.66, 21.15 ± 0.66 and 45.15 ± 0.56 μM, respectively. Compounds (5–6 ) showed anti-inflammatory activity in LPS-induced RAW 264.7 macrophages with the IC50 values of 43.95 ± 6.11 and 33.50 ± 2.04 μM, respectively. Graphical abstract: