Intramolecular N–Me and N–H aminoetherification for the synthesis of N-unprotected 3-amino-O-heterocycles. Issue 3 (5th January 2021)

• Record Type: Journal Article
• Authors: Paudyal, Mahesh P.; Wang, Mingliang; Siitonen, Juha H.; Hu, Yimin; Yousufuddin, Muhammed; Shen, Hong C.; Falck, John R.; Kürti, László
• Is Part Of: Organic & biomolecular chemistry. Volume 19:Issue 3(2020)
• Page Start: 557
• Page End: 560
• Publication Date: 2021-01-05
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d0ob02122a
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A mild Rh-catalyzed method for synthesis of cyclic unprotected N–Me and N–H 2, 3-aminoethers using an olefin aziridination–aziridine ring-opening domino reaction has been developed. Abstract : A mild Rh-catalyzed method for synthesis of cyclic unprotected N–Me and N–H 2, 3-aminoethers using an olefin aziridination–aziridine ring-opening domino reaction has been developed. The method is readily applicable to the stereocontrolled synthesis of a variety of 2, 3-disubstituted aminoether O-heterocyclic scaffolds, including tetrahydrofurans, tetrahydropyrans and chromanes.