Rh(iii)-Catalyzed three-component cascade annulation to produce the N-oxopropyl chain of isoquinolone derivatives. Issue 3 (5th January 2021)

• Record Type: Journal Article
• Authors: He, Yuan; Liao, Xian-Zhang; Dong, Lin; Chen, Fen-Er
• Is Part Of: Organic & biomolecular chemistry. Volume 19:Issue 3(2020)
• Page Start: 561
• Page End: 567
• Publication Date: 2021-01-05
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d0ob02389b
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Developing powerful methods to introduce versatile functional groups at the N -substituents of isoquinolone scaffolds is still a great challenge. Abstract : Developing powerful methods to introduce versatile functional groups at the N -substituents of isoquinolone scaffolds is still a great challenge. Herein, we report a novel three-component cascade annulation reaction to efficiently construct the N -oxopropyl chain of isoquinolone derivatives via rhodium(iii )-catalyzed C–H activation/cyclization/nucleophilic attack, with oxazoles used both as the directing group and potential functionalized reagents.