Relationship between arginase genes polymorphisms and preschool wheezing phenotypes. Issue 2 (23rd December 2020)

• Record Type: Journal Article
• Authors: Gokmirza Ozdemir, Pinar; Eker, Damla; Celik, Velat; Beken, Burcin; Gurkan, Hakan; Yazicioglu, Mehtap; Sut, Necdet
• Is Part Of: Pediatric pulmonology. Volume 56:Issue 2(2021)
• Page Start: 561
• Page End: 570
• Publication Date: 2020-12-23
• Subjects: ARG1 -- ARG2 -- polymorphism -- preschool wheezing -- recurrent wheezing -- single nucleotide -- SNP -- wheezing phenotype; Pediatric respiratory diseases -- Periodicals; Pediatrics -- Periodicals; 618.922
• DOI: 10.1002/ppul.25202
• Languages: English
• ISSNs: 8755-6863

Abstract

Abstract: Background: The association between arginase I ( ARG1 ) and arginase II ( ARG2 ) genes and asthma has been reported in previous studies, but associations between polymorphisms in ARG genes and preschool wheezing (PSW) phenotypes are still unknown. Objective: To examine the association between genetic variation in ARG1 and ARG2 genes and PSW phenotypes. Methods: We enrolled 83 patients and 86 healthy controls. The patient group included two subgroups: episodic wheezing (EW) ( n = 42, median age 41 months) and multiple‐trigger wheezing (MW) ( n = 41, median age 39 months). We genotyped six single nucleotide polymorphisms (SNPs) in ARG1 and six SNPs in ARG2 . Eighteen haplotypes for ARG1 and 31 haplotypes for ARG2 were constituted, and the distributions of SNPs and haplotypes in patients and controls were analyzed. Results: The frequency of the homozygote cytosine‐cytosine (CC) genotype of ARG1 rs2781667T>C SNP and the ARG1 haplotype 4 in the MW group was significantly higher than the EW group ( p = .002; odd ratios [OR]: 5.25; confidence interval [CI]: 1.9–14.51 and p < .001; OR: 7.77; CI: 2.54–23.74, respectively). The frequency of the ARG1 haplotype 5 was significantly higher but the frequency of ARG1 haplotype 9 was significantly lower in the all patients than in the healty controls ( p = .019; OR: 10.34; CI: 1.28–83.53 and p = .015; OR: 0.093; CI:0.01–0.74, respectively). The frequency of the ARG1 haplotype 2 was significantly higher in the EW group than in the MW group ( p = .014; OR: 5.68; CI: 1.48–21.8). Conclusion: Variations in ARG1 may potentially be related to phenotypes and risk of PSW.