A case of anti‐laminin 332 mucous membrane pemphigoid manifesting as desquamative gingivitis. Issue 1 (29th June 2020)

• Record Type: Journal Article
• Authors: Maeda, Sahoko Imai; Fujiwara, Kumiko; Tomihara, Kei; Yamazaki, Manabu; Imaue, Shuichi; Noguchi, Makoto
• Is Part Of: Oral science international. Volume 18:Issue 1(2021)
• Page Start: 73
• Page End: 77
• Publication Date: 2020-06-29
• Subjects: Anti‐laminin 332 -- desquamative gingivitis -- direct immunofluorescence microscopy -- mucous membrane pemphigoid; Oral medicine -- Periodicals; Mouth -- Diseases -- Periodicals; Mouth -- Diseases; Oral medicine; Oral Medicine -- Periodicals; Stomatognathic Diseases -- Periodicals; Periodicals; 617.522
• DOI: 10.1002/osi2.1073
• Languages: English
• ISSNs: 1348-8643

Abstract

Abstract: Anti‐laminin 332 mucous membrane pemphigoid (MMP) is characterized by circulating anti‐laminin 332 autoantibodies, with a high risk of concurrent malignant neoplasms. We report a case of anti‐laminin 332 MMP manifesting as a desquamative gingivitis. A 45‐year‐old woman experienced painful erythema and occasional bullous lesions on the gingiva despite good oral hygiene and plaque control. Intraoral examination revealed gingival inflammation with desquamation. Biopsy showed subepithelial cleft formation suggesting a subepidermal blister. Direct immunofluorescence revealed the deposition of IgG and IgA in the epithelium. Accordingly, we diagnosed anti‐laminin 332 MMP and treated with systemic corticosteroids. The oral lesion resolved after 3 months.