SPATA4 improves aging‐induced metabolic dysfunction through promotion of preadipocyte differentiation and adipose tissue expansion. Issue 1 (13th December 2020)

• Record Type: Journal Article
• Authors: Li, Zhongchi; Xu, Kang; Zhao, Sen; Guo, Yannan; Chen, Huiling; Ni, Jianquan; Liu, Qingfei; Wang, Zhao
• Is Part Of: Aging cell. Volume 20:Issue 1(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-12-13
• Subjects: adipocyte differentiation -- aging -- fat redistribution -- SPATA4; Cells -- Aging -- Periodicals; 571.8783605
• DOI: 10.1111/acel.13282
• Languages: English
• ISSNs: 1474-9718

Abstract

Abstract: Spermatogenesis‐associated protein 4 (SPATA4) is conserved across multiple species. However, the function of this gene remains largely unknown. In this study, we generated Spata4 transgenic mice to explore tissue‐specific function of SPATA4. Spata4 overexpression mice displayed increased subcutaneous fat tissue compared with wild‐type littermates at an old age, while this difference was not observed in younger mice. Aging‐induced ectopic fat distribution, inflammation, and insulin resistance were also significantly attenuated by SPATA4. In vitro, SPATA4 promoted preadipocyte differentiation through activation of the ERK1/2 and C/EBPβ pathway and increased the expression of adipokines. These data suggest SPATA4 can regulate lipid accumulation in a tissue‐specific manner and improve aging‐induced dysmetabolic syndromes. Clarifying the mechanism of SPATA4 functioning in lipid metabolism might provide novel therapeutic targets for disease interventions. Abstract : SPATA4 promotes preadipocyte differentiation through activation of ERK1/2 and C/EBPβ pathway, attenuates aging‐induced ectopic distribution of fat, and improves metabolic homeostasis.