Obesity‐related asthma in children: A role for vitamin D. Issue 2 (8th December 2020)

• Record Type: Journal Article
• Authors: O'Sullivan, Brian P.; James, Laura; Majure, Joseph M.; Bickel, Scott; Phan, Ly‐Thao; Serrano Gonzalez, Monica; Staples, Heather; Tam‐Williams, Jade; Lang, Jason; Snowden, Jessica
• Is Part Of: Pediatric pulmonology. Volume 56:Issue 2(2021)
• Page Start: 354
• Page End: 361
• Publication Date: 2020-12-08
• Subjects: asthma -- children -- inflammation -- obesity -- pediatric -- vitamin D; Pediatric respiratory diseases -- Periodicals; Pediatrics -- Periodicals; 618.922
• DOI: 10.1002/ppul.25053
• Languages: English
• ISSNs: 8755-6863

Abstract

Abstract: Excess adipose tissue predisposes to an enhanced inflammatory state and can contribute to the pathogenesis and severity of asthma. Vitamin D has anti‐inflammatory properties and low‐serum levels are seen in children with asthma and in children with obesity. Here we review the intersection of asthma, obesity, and hypovitaminosis D in children. Supplementation with vitamin D has been proposed as a simple, safe, and inexpensive adjunctive therapy in a number of disease states. However, little research has examined the pharmacokinetics of vitamin D and its therapeutic potential in children who suffer from obesity‐related asthma.