Free‐radical Initialized Cyclization of 2‐(3‐Arylpropioloyl)benzaldehydes with Toluene Derivatives: Access to Benzylated 1, 4‐Naphthoquinones via Copper‐Catalyzed Cascade Reaction. Issue 2 (13th November 2020)

• Record Type: Journal Article
• Authors: Zhu, Bingbin; Han, Hang; Su, Wei‐Ke; Yu, Chuanming; Jiang, Xinpeng
• Is Part Of: Advanced synthesis & catalysis. Volume 363:Issue 2(2021)
• Page Start: 484
• Page End: 489
• Publication Date: 2020-11-13
• Subjects: Benzyl radical -- Acylbenzylation -- Alkynones -- 1, 4-Naphthoquinones -- Cascade cyclization; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.202000975
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: A copper‐catalyzed cyclization reaction of 2‐(3‐arylpropioloyl)benzaldehydes was developed, leading to benzylated 1, 4‐naphthoquinones via radical‐triggered cascade cyclization. This example of an acylbenzylation involving internal alkynes could be carried out with a broad substrate scope and wide functional group tolerance. Abstract :