Cover Feature: Polypyridyl‐Based Copper Phenanthrene Complexes: Combining Stability with Enhanced DNA Recognition (Chem. Eur. J. 3/2021). Issue 3 (22nd October 2020)

• Record Type: Journal Article
• Authors: Fantoni, Nicoló Zuin; Molphy, Zara; O'Carroll, Sinéad; Menounou, Georgia; Mitrikas, George; Krokidis, Marios G.; Chatgilialoglu, Chryssostomos; Colleran, John; Banasiak, Anna; Clynes, Martin; Roche, Sandra; Kelly, Suainibhe; McKee, Vickie; Kellett, Andrew
• Is Part Of: Chemistry. Volume 27:Issue 3(2021)
• Page Start: 828
• Page End: 828
• Publication Date: 2020-10-22
• Subjects: copper -- DNA damage -- DNA repair -- electrochemistry -- EPR spectroscopy; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.202003314
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract : A new class of DNA intercalating metallodrug is reported . These agents contain a polypyridyl caging ligand called DPA which is bound to a copper ion ligated to a phenanthrene (Phen) DNA intercalator. The lead agent is Cu‐DPA‐DPPZ and it can recognize the minor groove of G–C rich DNA sequences and displays promising activity against several pancreatic cancer cell lines. The graphic shows the Cu‐DPA‐DPPZ complex intercalating the minor groove of a G–C DNA sequence taken from the protein data bank (2ANA). The modeling was completed using PyMOL together with the X‐ray crystal structure of the complex. More information can be found in the Full Paper by A. Kellett et al. on page 971 .