The time course of neuromuscular impairment during short‐term disuse in young women. Issue 1 (11th January 2021)

• Record Type: Journal Article
• Authors: MacLennan, Rob J.; Ogilvie, David; McDorman, John; Vargas, Ernest; Grusky, Arielle R.; Kim, Youngdeok; Garcia, Jeanette M.; Stock, Matt S.
• Is Part Of: Physiological reports. Volume 9:Issue 1(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-01-11
• Subjects: disuse -- motor unit -- muscle -- voluntary activation -- weakness; Physiology -- Periodicals; 571
• DOI: 10.14814/phy2.14677
• Languages: English
• ISSNs: 2051-817X

Abstract

Abstract: Skeletal muscle disuse results in rapid functional declines. Previous studies have typically been at least 1 week in duration and focused on the responsiveness of men. Herein, we report the timeline of initial impairments in strength, voluntary activation (VA), and motor unit control during 2 weeks of knee joint immobilization. Thirteen women (mean age =21 years) underwent 2 weeks of left knee joint immobilization via ambulation on crutches and use of a brace. Participants visited the laboratory for testing on seven occasions (two familiarization visits, pretest, 48 and 72 h, 1 and 2 weeks). Knee extensor isometric and concentric isokinetic strength at two velocities (180 and 360 degrees⋅s −1 ), VA, and submaximal vastus lateralis motor unit activity were evaluated. Moderate‐to‐large decreases in isometric and concentric strength at 180 degrees⋅s −1 and VA were observed within 48 hours. Isometric strength continued to decline beyond 72 h, whereas other variables plateaued. The B ‐term of the motor unit mean firing rate versus action potential amplitude relationship demonstrated a moderate increase 1 week into immobilization, suggesting that greater firing rates were necessary to maintain pretest torque levels. Concentric strength at a velocity of 360 degrees s −1 was not affected. Decreases in knee extensor strength occur within a matter of days after immobilization, although the time course and magnitude vary among assessment methods. These changes are mediated by the nervous system's capacity to activate skeletal muscle. Clinically appropriate interventions which target nervous system plasticity should be implemented early to minimize the rapid functional impairments associated with disuse. Abstract : The need to immobilize the knee joint is common following injury and surgery. Our findings demonstrate rapid and large decreases in maximal strength and neuromuscular function (voluntary activation and motor unit behavior) within 1 week of knee joint immobilization in young women. For clinicians, these findings highlight the need for early interventions that may mitigate immobilization‐induced declines in muscle function.