Emotion processing and regulation in major depressive disorder: A 7T resting‐state fMRI study. Issue 3 (5th November 2020)

• Record Type: Journal Article
• Authors: Ebneabbasi, Amir; Mahdipour, Mostafa; Nejati, Vahid; Li, Meng; Liebe, Thomas; Colic, Lejla; Leutritz, Anna Linda; Vogel, Matthias; Zarei, Mojtaba; Walter, Martin; Tahmasian, Masoud
• Is Part Of: Human brain mapping. Volume 42:Issue 3(2021)
• Page Start: 797
• Page End: 810
• Publication Date: 2020-11-05
• Subjects: amplitude of low frequency fluctuations -- emotion processing -- emotion regulation -- functional connectivity -- major depressive disorder; Brain mapping -- Periodicals; 611.81
• DOI: 10.1002/hbm.25263
• Languages: English
• ISSNs: 1065-9471

Abstract

Abstract: Dysfunctions in bottom‐up emotion processing (EP), as well as top‐down emotion regulation (ER) are prominent features in pathophysiology of major depressive disorder (MDD). Nonetheless, it is not clear whether EP‐ and ER‐related areas are regionally and/or connectively disturbed in MDD. In addition, it is yet to be known how EP‐ and ER‐related areas are interactively linked to regulatory behavior, and whether this interaction is disrupted in MDD. In our study, regional amplitude of low frequency fluctuations (ALFF) and whole‐brain functional connectivity (FC) of meta‐analytic‐driven EP‐ and ER‐related areas were compared between 32 healthy controls (HC) and 20 MDD patients. Then, we aimed to investigate whether the EP‐related areas can predict the ER‐related areas and regulatory behavior in both groups. Finally, the brain–behavior correlations between the EP‐ and ER‐related areas and depression severity were assessed. We found that: (a) affective areas are regionally and/or connectively disturbed in MDD; (b) EP‐ER interaction seems to be disrupted in MDD; overburden of emotional reactivity in amygdala may inversely affect cognitive control processes in prefrontal cortices, which leads to diminished regulatory actions. (c) Depression severity is correlated with FC of affective areas. Our findings shed new lights on the neural underpinning of affective dysfunctions in depression. Abstract : This study aims to identify whether EP‐ and ER‐related areas are regionally and/or connectively disturbed in MDD and how EP‐ and ER‐related areas are interactively linked to regulatory behavior, and whether this interaction is disrupted in MDD. Our findings demonstrated that (a) MDD is associated with regional and/or connectivity alterations of EP‐ and ER‐related areas; (b) EP‐ER interaction seems to be disrupted in MDD; (c) depression severity is correlated with FC of EP‐ and ER‐ related areas.