Teaching photosensitizers a new trick: red light-triggered G-quadruplex alkylation by ligand co-localization. Issue 8 (6th January 2021)

• Record Type: Journal Article
• Authors: Cadoni, Enrico; Manicardi, Alex; Fossépré, Mathieu; Heirwegh, Kaat; Surin, Mathieu; Madder, Annemieke
• Is Part Of: Chemical communications. Volume 57:Issue 8(2021)
• Page Start: 1010
• Page End: 1013
• Publication Date: 2021-01-06
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d0cc06030e
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A red-light triggered G-quadruplex photoalkylation procedure is reported, based on a bi-molecular approach involving the irradiation of a G4-binding photosensitizer in presence of a furan-containing G4-ligand. Abstract : We propose a bimolecular approach for G-quadruplex alkylation, using a pro-reactive furan-containing ligand, activated by red-light irradiation of a proximate G4-binding photosensitizer. G4- over dsDNA alkylation can be achieved selectively and proves high-yielding at low ligand excess. HPLC and modelling studies allowed identifying potential residues involved in the alkylation.