Hydroxyl Assisted, Photoredox/Cobalt Co‐catalyzed Semi‐Hydrogenation and Tandem Cyclization of o‐Alkynylphenols for Access to 2, 3‐Dihydrobenzofurans. Issue 3 (14th December 2020)

• Record Type: Journal Article
• Authors: Tian, Wan‐Fa; Zhu, Yao; He, Yong‐Qin; Wang, Mei; Song, Xian‐Rong; Bai, Jiang; Xiao, Qiang
• Is Part Of: Advanced synthesis & catalysis. Volume 363:Issue 3(2021)
• Page Start: 730
• Page End: 736
• Publication Date: 2020-12-14
• Subjects: cyclization -- cobalt catalysis -- photoredox catalysis -- semi-hydrogenation -- 2, 3-dihydrobenzofuran; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.202000986
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: Herein, a hydroxyl assisted, photoredox/cobalt co‐catalyzed semi‐hydrogenation and tandem cyclization of o ‐alkynylphenols is developed towards direct assembly of 2, 3‐dihydrobenzofurans. Moderate to good yields were obtained for a range of sterically and electronically diverse 2‐propynolphenols under mild conditions. Mechanistic studies demonstrated the inevitable role of the alcoholic hydroxyl group with (Z)‐alkene as the real intermediate. Finally, a key low‐valent cobalt catalyzed intramolecular hydroetherification of alkene is proposed. Abstract :