Use of cardiac radiation therapy as bridging therapy to CAR‐T for relapsed pediatric B‐cell acute lymphoblastic leukemia. Issue 3 (23rd December 2020)

• Record Type: Journal Article
• Authors: Marquez, Cesar P.; Montiel‐Esparza, Raul; Hui, Caressa; Schultz, Liora M.; Davis, Kara L.; Hoppe, Richard T.; Donaldson, Sarah S.; Ramakrishna, Sneha; Hiniker, Susan M.
• Is Part Of: Pediatric blood & cancer. Volume 68:Issue 3(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-12-23
• Subjects: B‐ALL -- CAR‐T -- pediatric oncology -- radiotherapy; Tumors in children -- Periodicals; Blood -- Diseases -- Periodicals; Cancer in children -- Periodicals; 618.92
• DOI: 10.1002/pbc.28870
• Languages: English
• ISSNs: 1545-5009

Abstract

Abstract: The use of radiotherapy as bridging therapy to chimeric antigen receptor T‐cell therapy (CAR‐T) in pre‐B acute lymphoblastic leukemia (B‐ALL) has been minimally explored. Here, we present a boy with B‐ALL who relapsed after allogeneic bone marrow transplant with disseminated disease, including significant symptomatic cardiovascular and gastrointestinal (GI) involvement. The cardiac and GI leukemic infiltrates were successfully treated with bridging radiation therapy (BRT) prior to CAR‐T infusion. Using this approach, he successfully tolerated CAR‐T with no evidence of disease or sequelae on 3‐month follow‐up. This is the first reported case of safe and effective delivery of cardiac BRT in B‐ALL.