Facing multidrug‐resistant pathogens in periprosthetic joint infections with self‐administered outpatient parenteral antimicrobial therapy—A prospective cohort study. Issue 2 (1st December 2020)

• Record Type: Journal Article
• Authors: Frieler, Sven; Hanusrichter, Yannik; Bellova, Petri; Geßmann, Jan; Schildhauer, Thomas A.; Baecker, Hinnerk
• Other Names: Schwarz Edward guestEditor.; Chen Antonia guestEditor.; Arts Jacobus J.C. guestEditor.
• Is Part Of: Journal of orthopaedic research. Volume 39:Issue 2(2021)
• Page Start: 320
• Page End: 332
• Publication Date: 2020-12-01
• Subjects: DTT -- MDR pathogen -- OPAT -- PJI -- two‐stage revision; Orthopedics -- Periodicals; Musculoskeletal system -- Periodicals; 616.7
• DOI: 10.1002/jor.24906
• Languages: English
• ISSNs: 0736-0266

Abstract

Abstract: A key factor in the successful management of periprosthetic joint infection (PJI) besides the surgical regime is a consistent antimicrobial therapy. Recently, oral versus intravenous (IV) antibiotics for bone and joint infection trial demonstrated the noninferiority of oral antimicrobial therapy compared to IV, implying that an early transition to oral administration is reasonable. It is likely that the international consensus meeting of musculoskeletal Infections and the European Bone and Joint Infection Society will consider these findings. However, rising levels of antimicrobial resistance are challenging and recommendations for dealing with multidrug‐resistant (MDR) pathogens resistant to oral antibiotics are lacking. This study focuses on establishing guidance towards their management in PJI. From December 2015 to June 2019, patients with MDR pathogens were included in a single‐center prospective cohort study and treated with self‐administered outpatient parenteral antimicrobial therapy (S‐OPAT) based on a two‐stage revision strategy. Demographics, pathogens, antimicrobial agents, and outcomes were recorded. A total of 1738 outpatient days in 26 patients were analyzed. The incidence of pathogens resistant to oral antibiotics in PJI was 4%, most frequently encountered were staphylococcus epidermidis. The Kaplan–Meier‐estimated infection‐free survival after 3 years was 90% (95% confidence interval, 84.6%–95.5%). We recorded adverse events in 6 of 54 (11%) S‐OPAT episodes (3.45/1000 S‐OPAT days). (i) S‐OPAT in two‐stage revision arthroplasty to counter increasing numbers of MDR pathogens resistant to oral agents can achieve a high infection eradication rate and (ii) should therefore be taken into account at the next society's consensus treatment updates.