Dried blood spots for anti‐doping: Why just going volumetric may not be sufficient. Issue 1 (22nd November 2020)

• Record Type: Journal Article
• Authors: Luginbühl, Marc; Gaugler, Stefan
• Is Part Of: Drug testing and analysis. Volume 13:Issue 1(2021)
• Page Start: 69
• Page End: 73
• Publication Date: 2020-11-22
• Subjects: anti‐doping -- dried blood spots -- hematocrit -- volumetric sampling -- WADA; Drugs -- Analysis -- Periodicals; Drug testing -- Periodicals; Chemistry, Forensic -- Periodicals; 615.1901
• DOI: 10.1002/dta.2977
• Languages: English
• ISSNs: 1942-7603

Abstract

Abstract : The perspective discusses quantitative DBS analysis for anti‐doping testing in an athletic population and why only using volumetric sampling for this subgroup might not be enough. It presents examples to highlight where HCT variations occur, followed by a whole blood to plasma ratio and an HCT extraction bias discussion. Finally, options to correct for the HCT bias are presented.