Association Between ALDH2 Polymorphism and Gastric Cancer Risk in Terms of Alcohol Consumption: A Meta‐Analysis. (16th December 2020)

• Record Type: Journal Article
• Authors: Joo Kang, Seung; Shin, Cheol Min; Sung, Joohon; Kim, Nayoung
• Is Part Of: Alcoholism. Volume 45:Number 1(2021)
• Page Start: 6
• Page End: 14
• Publication Date: 2020-12-16
• Subjects: Gastric Cancer -- Alcohol -- ALDH2 -- Meta‐analysis; Alcoholism -- Periodicals; Alcoholism -- Periodicals; Alcoolisme; Electronic journals; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.861005
• DOI: 10.1111/acer.14508
• Languages: English
• ISSNs: 0145-6008

Abstract

Abstract : Background: Alcohol may increase gastric cancer risk. Alcohol can be more carcinogenic in persons who possess inactive ALDH2 . The aim of this meta‐analysis was to evaluate whether ALDH2 polymorphism can affect alcohol‐induced gastric carcinogenesis. Methods: We searched the PubMed, EMBASE, and Cochrane databases to identify relevant articles published between January 2000 and September 2019. Eligible articles were selected according to inclusion and exclusion criteria. The data were analyzed using Review Manager 5.3. Results: A total of 7 case–control studies on ALDH2 rs671 polymorphism consisting of 3, 251 gastric cancer cases and 4, 943 controls were included in the analysis. Inactive ALDH2 genotypes (G/A or A/A) were associated with an increased risk of gastric cancer (odds ratio [OR] = 1.26, 95% confidence interval [CI]: 1.04 to 1.52, p = 0.02, I 2 = 64%), compared with active ALDH2 (G/G genotype). Subgroup analysis by alcohol consumption showed that inactive ALDH2 increased risk for gastric cancer in moderate to heavy drinkers (OR = 1.85, 95% CI: 1.52 to 2.25, p < 0.01, I 2 = 6%) more than in nondrinkers or mild drinkers (OR = 1.19; 95% CI: 1.05 to 1.36, p < 0.01, I 2 = 6%). Moderate/heavy alcohol consumption increased gastric cancer risk in individuals with inactive ALDH2 (OR = 2.23, 95% CI: 1.63 to 3.05, p < 0.01, I 2 = 30%) more than those with active ALDH2 (OR = 1.40, 95% CI: 0.98 to 2.01, p = 0.07, I 2 = 85%). Conclusions: The ALDH2 polymorphism modifies the risk of gastric cancer. Moderate/heavy drinkers are more susceptible to gastric cancer than non‐drinkers or light drinkers with inactive ALDH2 . Abstract : Alcohol may increase the risk of gastric cancer. Alcohol can be more carcinogenic in persons with inactive ALDH2. The aim of this meta‐analysis was to evaluate whether ALDH2 polymorphism can affect alcohol‐induced gastric carcinogenesis. We found that inactive ALDH2 increased the risk for gastric cancer in moderate to heavy drinkers (OR = 1.85, 95% CI: 1.52 to 2.25, p < 0.01, I 2 = 6%) more than in non‐drinkers or mild drinkers (OR = 1.19; 95% CI: 1.05 to 1.36, p < 0.01, I 2 = 6%). Strict alcohol abstinence should be recommended in individuals who possess inactive ALDH2 .