Sonochemically Synthesized Zinc Oxide Nanoflakes Based Electrochemical Immunosensor for Ethyl Glucuronide (EtG) Detection. (25th October 2017)

• Record Type: Journal Article
• Authors: Alam, Fahmida; Sinha, Raju; Jalal, Ahmed Hasnain; Manickam, Pandiaraj; Vabbina, Phani Kiran; Bhansali, Shekhar; Pala, Nezih
• Is Part Of: ECS transactions. Volume 80:Number 10(2017)
• Page Start: 1287
• Page End: 1294
• Publication Date: 2017-10-25
• Subjects: Electrochemistry -- Periodicals; Electrochemistry; Periodicals; Electronic journals; Electronic journal; 541.37
• DOI: 10.1149/08010.1287ecst
• Languages: English
• ISSNs: 1938-5862

Abstract

Abstract : Continuous monitoring of alcohol detection is imperative for the prevention of accidents, point of care monitoring, and personal safety. The cutting-edge technologies are mostly focused to detect alcohol from the breath (e.g. breathalyzer), which is not compatible for the real-time monitoring. The relationship between the blood and breath alcohol concentrations and the improvement of the detection techniques of alcohol biomarkers from the sweat render an opportunity for point of care monitoring. Due to its prolonged existence in sweat, Ethylglucuronide (EtG) is considered as one of the most promising biomarkers for alcohol detection. We report on label-free highly sensitive electrochemical immunosensor for the detection and the quantification of EtG based on sonochemically synthesized two-dimensional (2D) zinc oxide (ZnO) nanoflakes (NFs) on flexible Au-coated polyethylene terephthalate (PET) substrate. Highly sensitive detection of EtG using cyclic voltammetry (CV) is achieved by immobilizing EtG antibody on the as-synthesized sensing electrodes of ZnO NFs.