Multifunctional NaYF4:Nd/NaDyF4 nanocrystals as a multimodal platform for NIR-II fluorescence and magnetic resonance imaging. Issue 2 (18th December 2020)

• Record Type: Journal Article
• Authors: Zhao, Junwei; Hu, Huishan; Liu, Wenquan; Wang, Xin
• Is Part Of: Nanoscale advances. Volume 3:Issue 2(2021)
• Page Start: 463
• Page End: 470
• Publication Date: 2020-12-18
• Subjects: 620.5
• DOI: 10.1039/d0na00846j
• Languages: English
• ISSNs: 2516-0230

Abstract

Abstract : Recently, multimodal imaging nanoprobes based on the complementary advantages of various imaging methods have attracted considerable attention due to their potential application in the biomedical field. Abstract : Recently, multimodal imaging nanoprobes based on the complementary advantages of various imaging methods have attracted considerable attention due to their potential application in the biomedical field. As important bioimaging nanoprobes, lanthanide-doped nanocrystals (NCs) would be expected to improve the related biophotonic technology through integrated multimodal bioimaging. Herein, water-soluble and biocompatible NaYF4 :Nd/NaDyF4 NCs were prepared by a solvothermal method combined with hydrophobic interaction with phospholipids as a capping agent. The NaYF4 :Nd/NaDyF4 NCs exhibit excellent colloidal stability under physiological conditions. Compared with the bare NaYF4 :Nd 3+ NCs, the second near-infrared (NIR-II, 1000–1700 nm) fluorescence intensities of Nd 3+ ions in the NaYF4 :Nd/NaDyF4 core–shell NCs at the emissions of 1058 nm and 1332 nm are enhanced by 3.46- and 1.75-fold, respectively. Moreover, the r 2 value of NaYF4 :Nd/NaDyF4 NCs as T 2 -weighted contrast agents is calculated to be 44.0 mM −1 s −1 . As a novel multimodal imaging nanoprobe, the NaYF4 :Nd/NaDyF4 NCs can be employed for both NIR-II fluorescence and magnetic resonance imaging (MRI). The phospholipid-modified NaYF4 :Nd/NaDyF4 NCs demonstrate in vitro and in vivo multimodal NIR-II fluorescence imaging and MRI of HeLa cells and tumors, respectively. This study provides an effective strategy for the development of novel multimodal probes for the medical application of nanomaterials.