Fragmentation of Plasmid DNA Produced by Gamma Radiation: A Theoretical Approach. (15th December 2011)

• Record Type: Journal Article
• Authors: Silva Silva, R. A. S. R. A. S.; Arruda-Neto Arruda-Neto, J. D. T. J. D. T.; Nieto Nieto, L. L.
• Other Names: Dague Dague E. E. Academic Editor.
• Is Part Of: ISRN biophysics. Volume 2012(2012)
• Publication Date: 2011-12-15
• Subjects: Biophysics -- Periodicals; Biophysics; Periodicals; 571.4
• DOI: 10.5402/2012/725350
• Languages: English
• ISSNs: 2090-7354

Abstract

Abstract : Breaks in DNA, resulting in fragmented parts, can be produced by ionizing radiation which, in turn, is the starting point in the search for novel physical aspects of DNA strands. Double-strand breaks in particular cause disruption of the DNA strand, splitting it into several fragments. In order to study effects produced by radiation in plasmid DNA, a new simple mechanical model for this molecule is proposed. In this model, a Morse-like potential and a high-LET component are used to describe the DNA-radiation interaction. Two power laws, used to fit results of the model, suggest that, firstly, distribution of fragment size is nonextensive and, secondly, that a transition phase is present in the DNA fragment distribution pattern.