Combined treatment with sitagliptin and vitamin D in a patient with latent autoimmune diabetes in adults. (27th May 2016)

• Record Type: Journal Article
• Authors: Rapti, E; Karras, S; Grammatiki, M; Mousiolis, A; Tsekmekidou, X; Potolidis, E; Zebekakis, P; Daniilidis, M; Kotsa, K
• Is Part Of: Endocrinology, diabetes & metabolism case reports. (2016)
• Publication Date: 2016-05-27
• Subjects: Adult -- Male -- White -- Greece; Pancreas -- Diabetes -- Vitamin D -- Insulin -- Latent Autoimmune Diabetes of Adults (LADA); Vision – blurred -- Weight loss -- Vomiting -- Polyuria -- Polydipsia -- Hypovitaminosis D -- Nausea -- GADA -- Haemoglobin A1c -- Urinalysis -- Glucose (blood) -- HLA genotyping -- Sitagliptin -- DPP4 inhibitors -- Vitamin D -- Gliclazide -- Sulphonylureas -- Metformin; Insight into disease pathogenesis or mechanism of therapy -- May -- 2016; Endocrinology -- Periodicals; Diabetes -- Periodicals; Diabetes Mellitus; Endocrinology; Diabetes; Endocrinology; Case Reports; Periodicals; Periodicals; 616.4
• DOI: 10.1530/EDM-15-0136
• Languages: English
• ISSNs: 2052-0573

Abstract

Summary: Latent autoimmune diabetes in adults (LADA) is a relatively new type of diabetes with a clinical phenotype of type 2 diabetes (T2D) and an immunological milieu characterized by high titers of islet autoantibodies, resembling the immunological profile of type 1 diabetes (T1D). Herein, we report a case of a young male, diagnosed with LADA based on both clinical presentation and positive anti-glutamic acid decarboxylase antibodies (GAD-abs), which were normalized after combined treatment with a dipeptidyl peptidase-4 inhibitor (DPP-4) (sitagliptin) and cholecalciferol. Learning points: Anti-glutamic acid decarboxylase antibodies (GAD-abs) titers in young patients being previously diagnosed as type 2 diabetes (T2D) may help establish the diagnosis of latent autoimmune diabetes in adults (LADA). Sitagliptin administration in patients with LADA might prolong the insulin-free period. Vitamin D administration in patients with LADA might have a protective effect on the progression of the disease.