Turner syndrome: don't forget the vulva. (1st May 2016)

• Record Type: Journal Article
• Authors: Haidopoulos, Dimitrios; Bakolas, George; Michala, Lina
• Is Part Of: Endocrinology, diabetes & metabolism case reports. (2016)
• Publication Date: 2016-05-01
• Subjects: Adult -- Female -- White -- Greece; Ovaries -- Gynaecological endocrinology -- Turner syndrome; Skin pigmentation – spotty -- Skin – texture change -- Lichen sclerosus -- Itching -- Pruritus -- Histopathology -- Resection of tumour; Dermatology -- Gynaecology; Unique/unexpected symptoms or presentations of a disease -- May -- 2016; Endocrinology -- Periodicals; Diabetes -- Periodicals; Diabetes Mellitus; Endocrinology; Diabetes; Endocrinology; Case Reports; Periodicals; Periodicals; 616.4
• DOI: 10.1530/EDM-16-0016
• Languages: English
• ISSNs: 2052-0573

Abstract

Summary: Turner syndrome (TS) has been linked to a number of autoimmune conditions, including lichen sclerosus (LS), at an estimated prevalence of 17%. LS is a known precursor to vulvar cancer. We present a case of vulvar cancer in a 44-year-old woman, who had previously complained of pruritus in the area, a known symptom of LS. Histology confirmed a squamous cell carcinoma with underlying LS. Vulvar assessment for the presence of LS should be undertaken regularly as part of the routine assessments proposed for adult TS women. If LS is identified, then the patient should be warned of the increased risk of vulvar cancer progression and should be monitored closely for signs of the condition. Learning points: Patients with TS are at increased risk of developing LS. LS is a known precursor to vulvar cancer. TS women with LS may be at risk of developing vulvar cancer and should be offered annual vulvar screening and also be aware of signs and symptoms of early vulvar cancer.