A chiral covalent organic framework (COF) nanozyme with ultrahigh enzymatic activity. Issue 12 (2nd November 2020)

• Record Type: Journal Article
• Authors: Zhou, Ya; Wei, Yue; Ren, Jinsong; Qu, Xiaogang
• Is Part Of: Materials horizons. Volume 7:Issue 12(2020)
• Page Start: 3291
• Page End: 3297
• Publication Date: 2020-11-02
• Subjects: Materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/d0mh01535k
• Languages: English
• ISSNs: 2051-6347

Abstract

Abstract : The first chiral nanozyme with higher activity than the natural enzyme is designed based on mimicking the natural enzyme and covalent organic frameworks. Abstract : Herein, we report the first chiral nanozyme with higher activity than the natural enzyme, which is designed based on mimicking a natural enzyme and the superior structure of covalent organic framework (COF) materials. The well-dispersed iron porphyrin and l -histidine (l -His) units endow the COF nanozyme with high activity. The incorporation of l -His units also imbues the COF nanozyme with selectivity for l -dopa in the oxidation of dopa enantiomers with a selectivity factor up to 1.86, while replacing l -His with d -His can reverse the preference to d -dopa with a selectivity factor of 1.51. The activity and selectivity of the COF nanozyme can be optimized by varying the l -His content which can change the activation energy of the catalytic reactions and the substrate binding.