An organocatalytic C–C bond cleavage approach: a metal-free and peroxide-free facile method for the synthesis of amide derivatives. (9th December 2020)

• Record Type: Journal Article
• Authors: Vodnala, Nagaraju; Gujjarappa, Raghuram; Polina, Saibabu; Satheesh, Vanaparthi; Kaldhi, Dhananjaya; Kabi, Arup K.; Malakar, Chandi C.
• Is Part Of: New journal of chemistry. Volume 44:Number 48(2020)
• Page Start: 20940
• Page End: 20944
• Publication Date: 2020-12-09
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/d0nj04158k
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : An organocatalyzed C–C bond cleavage approach has been envisioned towards the synthesis of amide derivatives from their corresponding amines and 1, 3-dicarbonyls. Abstract : A facile organocatalytic approach has been devised towards the synthesis of amide derivatives using 1, 3-dicarbonyls as easily available acyl-sources under peroxide-free reaction conditions. This transformation was accomplished by the cleavage of the C–C bond in the presence of TEMPO as an organocatalyst and excludes the use of transition-metals and harsh reaction conditions. A broad range of substrates with diverse functional groups were well tolerated and delivered the products in high yields.