Palladium-catalyzed synthesis of spirooxindoles and [3, 4]-fused oxindoles from alkene-tethered carbamoyl chlorides. Issue 2 (27th November 2020)

• Record Type: Journal Article
• Authors: Yang, Fang; Sun, Wan; Meng, Haifang; Chen, Mengjia; Chen, Chen; Zhu, Bolin
• Is Part Of: Organic chemistry frontiers. Volume 8:Issue 2(2021)
• Page Start: 283
• Page End: 287
• Publication Date: 2020-11-27
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/d0qo01166e
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : We disclosed an efficient Pd-catalyzed domino reaction for the synthesis of spirooxindoles and [3, 4]-fused oxindoles from alkene-tethered carbamoyl chlorides. Abstract : We disclosed an efficient Pd-catalyzed domino reaction for facile synthesis of spirooxindoles and [3, 4]-fused oxindoles from alkene-tethered carbamoyl chlorides. The five-membered C, C -palladacycle obtained through intramolecular C–H activation should act as the key intermediate in both catalytic cycles. A variety of functionalized spirooxindoles and [3, 4]-fused oxindoles were synthesized in moderate to good yields.