Palladium(ii)-catalyzed three-component tandem reactions: synthesis of multiply substituted quinolines. Issue 2 (23rd November 2020)

• Record Type: Journal Article
• Authors: Zhang, Yetong; Chen, Lepeng; Shao, Yinlin; Zhang, Fangjun; Chen, Zhongyan; Lv, Ningning; Chen, Jiuxi; Li, Renhao
• Is Part Of: Organic chemistry frontiers. Volume 8:Issue 2(2021)
• Page Start: 254
• Page End: 259
• Publication Date: 2020-11-23
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/d0qo01179g
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : The three-component tandem reaction of 2-aminobenzonitriles, arylboronic acids and ketones as available reagents allowing the synthesis of polysubstitution quinolines is reported. Abstract : The three-component tandem reaction of 2-aminobenzonitriles, arylboronic acids and ketones allowing the synthesis of polysubstitution quinolines is reported. This strategy presents a practical, efficient, one-pot procedure that delivers functional quinolines in moderate to good yields with high functional group tolerance. To enrich the synthetic applications in accessing diverse quinolines, a new method for the introduction of halogen substituents into target products has been developed as well, which shows potential for further synthetic elaborations.