Seroprevalence of Nipah Virus Infection in Peninsular Malaysia. (11th May 2020)

• Record Type: Journal Article
• Authors: Yong, Ming-Yen; Lee, Soo-Ching; Ngui, Romano; Lim, Yvonne Ai-Lian; Phipps, Maude E; Chang, Li-Yen
• Is Part Of: Journal of infectious diseases. Volume 221(2020)Supplement 4
• Page Start: S370
• Page End: S374
• Publication Date: 2020-05-11
• Subjects: Nipah virus -- serosurveillance -- Malaysia -- indigenous population -- comparative indirect ELISA -- nucleocapsid protein; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiaa085
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: Nipah virus (NiV) outbreak occurred in Malaysia in 1998. The natural host reservoir for NiV is Pteropus bats, which are commonly found throughout Malaysia. Humans become infected when NiV spills over from the reservoir species. In this study, NiV serosurveillance in Peninsular Malaysia, particularly among the indigenous population, was performed. The collected samples were tested for presence of NiV antibodies using a comparative indirect enzyme-linked immunosorbent assay based on the recombinant NiV nucleocapsid (rNiV-N) protein. We found that 10.73% of the participants recruited in this study had antibodies against rNiV-N, suggesting possible exposure to NiV.