An ESIPT-induced NIR fluorescent probe to visualize mitochondrial sulfur dioxide during oxidative stress in vivo. Issue 5 (21st December 2020)

• Record Type: Journal Article
• Authors: Ren, Haixian; Huo, Fangjun; Wu, Xia; Liu, Xiaogang; Yin, Caixia
• Is Part Of: Chemical communications. Volume 57:Issue 5(2021)
• Page Start: 655
• Page End: 658
• Publication Date: 2020-12-21
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d0cc07398a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : An ESIPT-induced NIR fluorescent probe can visualize mitochondrial sulfur dioxide during oxidative stress in vivo . Abstract : Based on the change in electron distribution of the benzopyrylium unit before and after sulfite addition, a 2-(2′-hydroxyphenyl)benzothiazole (HBT)-based fluorophore generated the excited state intramolecular proton transfer (ESIPT) process with a near-infrared enhanced emission at 836 nm and a large Stokes shift (286 nm). The probe was applied to image SO2 derivatives in cells and mice. Our data will provide new ideas for the development of ESIPT-based fluorescence probe with longer wavelength emission.