Hybrid ZnO/chitosan antimicrobial coatings with enhanced mechanical and bioactive properties for titanium implants. (1st April 2021)

• Record Type: Journal Article
• Authors: Lin, Ming-Hong; Wang, Yan-Hsiung; Kuo, Cheng-Hsien; Ou, Shih-Fu; Huang, Pin-Zhen; Song, Tzu-Yu; Chen, Yi-Cheng; Chen, Shyi-Tien; Wu, Chien-Hui; Hsueh, Yi-Huang; Fan, Fang-Yu
• Is Part Of: Carbohydrate polymers. Volume 257(2021)
• Publication Date: 2021-04-01
• Subjects: Chitosan -- Nanoporous Ti oxide -- Bioactivity -- Antibacterial activity; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2021.117639
• Languages: English
• ISSNs: 0144-8617

Abstract

Graphical abstract: Highlights: Chitosan coatings containing ZnO particle were deposited on porous Ti oxide. Chitosan/ZnO coating had a higher ability to inhibit E. coli adhesion than chitosan. Chitosan/ZnO exhibited a higher bioactivity due to Zn 2+ ion release. Adhesive strength of coating increased with the amount of ZnO in the coatings. Chitosan/ZnO coatings improved the corrosion resistance of Ti in solution. Abstract: A biocomposite coating comprising chitosan and ZnO deposited on a porous Ti oxide is developed to avoid orthopedic and dental implant-related infections. The coating comprised of an inner layer of nanoporous TiO2 and the outer layer of the chitosan matrix with ZnO nanoparticles. Microbiological tests show that chitosan coating is effective against Escherichia coli (E. coli), however, its ability to inhibit bacterial adhesion is very limited. A 1.2-fold increase in the antibacterial activity of chitosan/ZnO coating against E. coli was detected as compared to the chitosan coating alone, and the chitosan/ZnO efficiently inhibited biofilm formation. In addition, the chitosan/ZnO coating exhibited improved bioactivity compared to the chitosan coating. The improvement in antibacterial properties and bioactivity of the chitosan/ZnO coating is attributed to the release of Zn 2+ ions. The critical force of scratching the chitosan/ZnO coating was approximately twice that of the chitosan coating. The potentiodynamic polarization results confirmed that the corrosion resistance of the implant with ZnO/chitosan/Ti structure was improved. In addition, cytocompatibility evaluation indicated that the chitosan/ZnO coating has good cytocompatibility in MG-63 cells as compared to pure Ti.