Fabrication of carboxymethyl chitosan/poly(ε-caprolactone)/doxorubicin/nickel ferrite core-shell fibers for controlled release of doxorubicin against breast cancer. (1st April 2021)

• Record Type: Journal Article
• Authors: Abasalta, Mahdi; Asefnejad, Azadeh; Khorasani, Mohammad Taghi; Saadatabadi, Ahmad Ramazani
• Is Part Of: Carbohydrate polymers. Volume 257(2021)
• Publication Date: 2021-04-01
• Subjects: N-carboxymethyl chitosan/poly(ε-caprolactone) -- Magnetic core-shell fibers -- Doxorubicin controlled release; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2021.117631
• Languages: English
• ISSNs: 0144-8617

Abstract

Graphical abstract: Highlights: N -Carboxymethyl chitosan/poly(ε-caprolactone) core-shell fibers were produced. Nickel ferrite and Doxorubicin were loaded into the nanofibers against breast cancer. The sustained release of DOX from core-shell fibers was obtained during 25 days. The external magnetic field and pH of 5.4 resulted in DOX release during 7 days. Maximum cytotoxicity was 83 % using CMC/PCL/nickel ferrite 10 % core-shell fibers. Abstract: The coaxial electrospinning for producing core-shell nanofibers due to control the release profile of drug by the shell layer has been developed. N -carboxymethyl chitosan (CMC)-polyvinyl alcohol (core)/poly(ε-caprolactone) (PCL) (shell) nanofibers were produced via coaxial electrospinning. Doxorubicin (DOX) and nickel ferrite nanoparticles were incorporated into the nanofibers for controlled release of DOX against MCF-7 breast cancer. The minimum CMC/PCL fiber diameter was found to be 300 nm by optimizing of three variables including voltage to distance ratio (1.5–2.5 kV/cm), CMC concentration (4−6 wt.%) and PCL concentration (8−12 wt.%). The synthesized core-shell fibers were characterized using FTIR, XRD, SEM, and TEM analysis. The extended release and controlled release of DOX from core-shell nanofibers were achieved under physiological pH without external magnetic field (EMF) and acidic pH with EMF during 25 and 7 days, respectively. The maximum cytotoxicity of MCF-7 breast cancer cells was about 83 % using CMC/PCL/nickel ferrite 10 % nanofibers and EMF.