Highly antifouling, biocompatible and tough double network hydrogel based on carboxybetaine-type zwitterionic polymer and alginate. (1st April 2021)

• Record Type: Journal Article
• Authors: Zhang, Jing; Chen, Lingdong; Chen, Liqun; Qian, Sunxiang; Mou, Xiaozhou; Feng, Jie
• Is Part Of: Carbohydrate polymers. Volume 257(2021)
• Publication Date: 2021-04-01
• Subjects: DN hydrogel -- Zwitterionic -- Antifouling -- Biocompatible -- Tough; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2021.117627
• Languages: English
• ISSNs: 0144-8617

Abstract

Graphical abstract: Highlights: A hybrid crosslinked DN hydrogel based on SA and PCBAA was successfully prepared. The DN structure endows the hydrogel with good mechanical properties. The DN hydrogel shows excellent resistance to biological pollutants. The DN hydrogel has high biocompatibility in vivo and in vitro . Abstract: Because of resistance to bio-macromolecular adhesion, antifouling hydrogels have attracted great attention in biomedical field. But traditional antifouling hydrogels made by hydrophilic polymers are always poor of mechanical properties. Herein, a new hybrid ionic-covalent cross-linked double network (DN) hydrogel was prepared by a simple one-pot method based on sodium alginate and the zwitterionic material carboxybetaine acrylamide (CBAA). The DN hydrogel has good mechanical properties, including high elastic modulus (0.28 MPa), high tensile strength (0.69 MPa), as well as good self-recovery capability. More importantly, the DN hydrogel is highly resistance to the adsorption of non-specific protein, cells, bacteria and algae, exhibiting an outstanding antifouling property. The in vitro and in vivo experiments prove that the DN hydrogel is highly biocompatible. This study provides a new strategy for the preparation of antifouling DN hydrogels with good mechanical properties for different needs, such as tissue scaffolds, wound dressings, implantable devices, and other fields.