A peptide-based aggregation-induced emission bioprobe for selective detection and photodynamic killing of Gram-negative bacteria. (4th November 2020)

• Record Type: Journal Article
• Authors: Bao, Pingping; Li, Cong; Ou, Hanlin; Ji, Shenglu; Chen, Yao; Gao, Jing; Yue, Xin; Shen, Jing; Ding, Dan
• Is Part Of: Biomaterials science. Volume 9:Number 2(2021)
• Page Start: 437
• Page End: 442
• Publication Date: 2020-11-04
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1039/d0bm01330g
• Languages: English
• ISSNs: 2047-4830

Abstract

Abstract : A bioprobe with aggregation-induced emission characteristics is developed, which can visualize and photodynamically ablate Gram-negative bacteria in a selective manner. Abstract : Herein, we report a new bioprobe with aggregation-induced emission (AIE) characteristics by conjugation of a far-red/near-infrared emissive AIE luminogen and two polymyxinB peptides. Due to the strong binding effect between polymyxin B and the lipopolysaccharide in the cell wall of Gram-negative bacteria, the bioprobe can selectively visualize Gram-negative bacteria and effectively kill them via photodynamic treatment.