Comparison of MOG and AQP4 antibody seroprevalence in Korean adults with inflammatory demyelinating CNS diseases. (May 2021)

• Record Type: Journal Article
• Authors: Hyun, Jae-Won; Lee, Hye Lim; Jeong, Woo Kyo; Lee, Hye Jung; Shin, Jong Hwa; Min, Ju-Hong; Kim, Byoung Joon; Kim, Seung Woo; Shin, Ha Young; Oh, Jeeyoung; Kim, Woojun; Shin, Hyun-June; Oh, Sun-Young; Kim, Hyunjin; Lim, Young-Min; Huh, So-Young; Cho, Eun Bin; Nam, Tai-Seung; Lee, Seung-Han; Kim, Sun-Young; Kang, Sa-Yoon; Han, Suk Geun; Sohn, Eun Hee; Baek, Seol-Hee; Kim, Byung-Jo; Lee, Sang-Soo; Seok, Jin Myoung; Hong, Yoon-Ho; Oh, Seong-il; Kim, Jong Kuk; Shin, Kyong Jin; Kwon, Ohyun; Cho, Joong-Yang; Bae, Jong Seok; Kim, So Yeon; Kim, Yeseul; Lee, Min Young; Kim, Su-Hyun; Kim, Ho Jin;
• Is Part Of: Multiple sclerosis. Volume 27:Number 6(2021)
• Page Start: 964
• Page End: 967
• Publication Date: 2021-05
• Subjects: Aquaporin-4 -- myelin oligodendrocyte glycoprotein -- prevalence -- adult; Central nervous system -- Diseases -- Periodicals; Myelin sheath -- Diseases -- Periodicals; Inflammation -- Periodicals; Multiple sclerosis -- Periodicals; Central Nervous System Diseases -- Periodicals; Demyelinating Diseases -- Periodicals; Inflammation -- Periodicals; Multiple Sclerosis -- Periodicals; Système nerveux central -- Maladies -- Périodiques; Gaine de myéline -- Maladies -- Périodiques; Inflammation (Pathologie) -- Périodiques; Sclérose en plaques -- Périodiques; Electronic journals; 616.834005
• DOI: 10.1177/1352458520948213
• Languages: English
• ISSNs: 1352-4585

Abstract

We aimed to compare seroprevalence of anti-myelin oligodendrocyte glycoprotein (MOG) and anti-aquaporin-4 (AQP4) antibodies in Korean adults with inflammatory demyelinating diseases (IDDs) of the central nervous system (CNS), based on a multicenter nationwide database. Sera were analyzed using a live cell–based assay for MOG and AQP4 antibodies. Of 586 Korean adults with IDDs of the CNS, 36 (6.1%) and 185 (31.6%) tested positive for MOG and AQP4 antibodies, respectively. No participant showed double positivity. Seroprevalence of MOG antibodies was about five times lower than that of AQP4 antibodies in a large cohort of Korean adults with IDDs of the CNS.