Fatty acid binding protein 4 (FABP4) and metabolic-related parameters in systemic lupus erythematosus active and non-active episode. (June 2021)

• Record Type: Journal Article
• Authors: Hamijoyo, Laniyati; Putri, Mirasari; Alita, Vilya Rizkiyanti; Atik, Nur; Syamsunarno, Mas Rizky AA
• Is Part Of: Lupus. Volume 30:Number 7(2021)
• Page Start: 1133
• Page End: 1139
• Publication Date: 2021-06
• Subjects: Systemic lupus erythematosus -- fatty acid binding protein 4 -- serum metabolite -- SLEDAI-2K; Systemic lupus erythematosus -- Periodicals; 616.772005
• DOI: 10.1177/09612033211006908
• Languages: English
• ISSNs: 0961-2033

Abstract

Objective: To assess serum FABP4 and other metabolic-related parameters in Systemic Lupus Erythematosus (SLE) active and non-active episode. Methods: Fifty-four SLE patients in Hasan Sadikin General Hospital, Bandung, Indonesia in 2018–2019 were recruited and serum samples were collected in their active and non-active episode status. Serum was analyzed for FABP4, leptin, glucose, and triglycerides. The clinical characteristics were analyzed from medical records. Disease activity was assessed with the SLEDAI-2K (≥4 defined as an active; <4 as non-active episode). Results: Significantly correlation of Systolic Blood Pressure (SBP) (p = 0.001, r = 0.59) and C3 (p = 0.04, r = 0.47) between active and non-active episode. In non-active episode, there was significant correlation of FABP4 with Diastolic Blood Pressure (DBP) (p = 0.04, r = 0.26) and blood glucose (p = 0.01, r = −0.39). In active episode, there was significant correlation FABP4 with SBP (p = 0.04, r = −0.28) and triglyceride (p = 0.002, r = 0.55). Conclusion: FABP4 correlates with high DBP in the non-active and high triglyceride serum in the active episode.