Association of antiphospholipid antibodies with clinical activity and renal pathological activity in patients with lupus nephritis. (June 2021)

• Record Type: Journal Article
• Authors: Zhang, Jianna; Zhang, Ji; Zhou, Qiongxiu; Lu, Guoyuan; You, Xiaohan
• Is Part Of: Lupus. Volume 30:Number 7(2021)
• Page Start: 1140
• Page End: 1145
• Publication Date: 2021-06
• Subjects: Lupus nephritis (LN) -- antiphospholipid antibodies (aPL) -- anticardiolipin antibodies -- disease activity; Systemic lupus erythematosus -- Periodicals; 616.772005
• DOI: 10.1177/09612033211006781
• Languages: English
• ISSNs: 0961-2033

Abstract

Objectives: This study aimed to investigate the association of antiphospholipid antibodies (aPL) with clinical activity and renal pathological activity in patients with lupus nephritis (LN). Methods: Levels of anticardiolipin () antibodies, anti-β2-glycoprotein I (anti-β2-GPI) antibodies and lupus anticoagulant (LAC) were measured, and other clinical and pathological data were also obtained during the same period before renal biopsy. Results: A total of 83 patients with LN were included in this study, 40 patients (48.2%) in the s positive group and 43 patients in the aPL negative group. LN patients with positive aPL had significantly higher SLEDAI (p = 0.012), more hematuria (p = 0.043), lower serum C3 (p = 0.003) and C4 (p = 0.014), and a higher pathological activity index (p = 0.012), more micro-thrombosis (p = 0.046) and more C3 deposits (p = 0.038) in the glomerulus than patients with negative aPL The level of IgG- was significantly correlated with SLEDAI and serum level of C3 (r = 0.44, p < 0.001; r = −0.39, p = 0.003, respectively). The level of IgM- was significantly correlated with SLEDAI, and serum levels of C3 and C4 (r = 0.27, p = 0.014; r = −0.22, p = 0.041; r = −0.23, p = 0.035, respectively). Conclusions: Our work suggests that aPL, especially, are correlated with both clinical activity and renal pathological activity in patients with LN.