Hippocampal Involvement With Vigabatrin-Related MRI Signal Abnormalities in Patients With Infantile Spasms: A Novel Finding. (June 2021)

• Record Type: Journal Article
• Authors: Harini, Chellamani; Yuskaitis, Christopher J.; Libenson, Mark H.; Yang, Edward; DeLeo, Michelle; Zhang, Bo; Mysak, Kate; Marti, Candice; Peters, Jurriaan M.; Bergin, Ann Marie; Pearl, Phillip L.; Prabhu, Sanjay P.
• Is Part Of: Journal of child neurology. Volume 36:Number 7(2021)
• Page Start: 575
• Page End: 582
• Publication Date: 2021-06
• Subjects: infantile spasms -- vigabatrin-related MRI changes -- hippocampus; Nervous system -- Diseases -- Periodicals; 618.928
• DOI: 10.1177/0883073820985395
• Languages: English
• ISSNs: 0883-0738

Abstract

Background: In a subset of infants exhibiting typical vigabatrin-related magnetic resonance imaging (MRI) changes, the authors observed additional hippocampal signal abnormalities. The authors investigated occurrence and significance of additional signal abnormalities. Methods: A retrospective review of infantile spasms patients with typical vigabatrin-related MRI abnormalities was performed. Atypical features included signal changes unilaterally or at previously unreported sites. Comparisons were made between patients with and without atypical features. Results: In all, 26/55 (47%) exhibited typical vigabatrin-related MRI changes, with additional signal abnormalities in the hippocampi in 6 of 26. On follow-up, evolution of hippocampal signal changes paralleled changes at typical locations in 4 patients. Two patients, clinically well, without follow-up MRI. Patients with and without additional hippocampal signal changes did not differ with respect to clinical factors, including seizure status. One patient had unilateral thalamic/cerebral peduncle signal abnormality along with typical vigabatrin changes. Conclusions: Hippocampal changes seen in subset of patients with typical vigabatrin-related changes may be attributable to vigabatrin exposure in the appropriate circumstance.