Monomorphic Epitheliotropic Intestinal T-cell Lymphoma of the Stomach: Two Case Reports and a Literature Review. (June 2021)

• Record Type: Journal Article
• Authors: Lu, Susu; Zhou, Gang; Chen, Min; Liu, Weiping; Zhao, Sha
• Is Part Of: International journal of surgical pathology. Volume 29:Number 4(2021)
• Page Start: 410
• Page End: 419
• Publication Date: 2021-06
• Subjects: monomorphic epitheliotropic intestinal T-cell lymphoma -- MEITL -- stomach -- T-cell receptor -- c-MYC -- EBER; Pathology, Surgical -- Periodicals; 617.07
• DOI: 10.1177/1066896920953906
• Languages: English
• ISSNs: 1066-8969

Abstract

We describe the clinicopathologic and molecular features of 2 cases of gastric monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL), which were first diagnosed from gastric biopsies, one was primary whereas the other was gastric involvement by MEITL. Both cases were older men with stomach ulcers. Case 1 was admitted for a hemorrhage in the upper digestive tract and case 2 for edema. Histology of both cases showed infiltrated monomorphic and medium-sized lymphocytes with lymphoid epithelial phenomenon. An inflammatory background and vascular hyperplasia were also observed likely due to the ulceration. Neoplastic cells expressed CD2, CD3, CD7, CD8, CD56, TIA-1, and MYC, not CD5, CD4, Granzyme B, CD20, CD30, TdT, or EBER. Both lymphomas showed TCRG gene rearrangement and c-MYC gains. Moreover, we first affirmed polysomy of chromosome 8 in case 2. For correct diagnosis of this rare tumor at the rare location, it is important that pathologists raise the possibility and exclude other differential diagnoses.