Functional crosstalk between Long non-coding RNAs and the NLRP3 inflammasome in the regulation of diseases. (March 2021)

• Record Type: Journal Article
• Authors: Luo, Deqiang; Liu, Fen; Zhang, Jianguo; Shao, Qiang; Tao, Wenqiang; Xiao, Rui; Dai, Wei; Qian, Kejian
• Is Part Of: Molecular immunology. Volume 131(2021)
• Page Start: 191
• Page End: 200
• Publication Date: 2021-03
• Subjects: Inflammatory inflammasome -- Inflammatory diseases -- NLRP3 -- Long-chain non-coding RNA; Immunochemistry -- Periodicals; Molecular biology -- Periodicals; Immunochemistry -- Periodicals; Allergy and Immunology -- Periodicals; Molecular Biology -- Periodicals; Immunochimie -- Périodiques; Biologie moléculaire -- Périodiques; Immunochemistry; Molecular biology; Periodicals; Electronic journals; 571.96
• DOI: 10.1016/j.molimm.2020.12.038
• Languages: English
• ISSNs: 0161-5890

Abstract

Highlights: Elucidating the mechanism of NLRP3 activation in disease. Five types of interactive functional crosstalk mechanism between lncRNAs and NLRP3 inflammasome are interpreted. Functional crosstalk mechanism between LncRNAs and NLRP3 inflammasomes in different diseases were systematically summarized. Abstract: Emerging evidence has indicated that long noncoding RNAs (lncRNAs) are involved in various pathophysiological processes of disease, such as cancer occurrence, viral invasion, and inflammatory damage. The main inflammatory body component, nod-like receptor protein 3 (NLRP3), is the trigger point of inflammatory reactions and inflammation-related diseases and coordinates the body's response to inflammation. At present, increasing evidence shows that the interaction of lncRNAs and the NLRP3 inflammasome plays an important role in the inflammatory response and different diseases. This may be involved in the development and progression of various diseases by activating signalling pathways and a variety of molecular regulatory mechanisms—this article reviews progress in research on the relationship between lncRNAs and the NLRP3 inflammasome under different conditions.