Photocatalytic Annulation‐Carbohalogenation of 1, 7‐Enynes for Atom‐Economic Synthesis of Functionalized 3, 4‐Dihydronaphthalen‐1(2H)‐ones. Issue 3 (8th December 2020)

• Record Type: Journal Article
• Authors: Ji, Wen‐Zhe; Shi, Hao‐Nan; Wei, Ping; Hao, Wen‐Juan; Tu, Shu‐Jiang; Jiang, Bo
• Is Part Of: Advanced synthesis & catalysis. Volume 363:Issue 3(2021)
• Page Start: 838
• Page End: 845
• Publication Date: 2020-12-08
• Subjects: Photocatalysis -- Annulation -- Atom-Economy -- 1, 7-Enynes -- 3, 4-Dihydronaphthalen-1(2H)-ones; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.202001125
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: A general and efficient photocatalytic annulation‐carbohalogenation of 1, 7‐enynes with a wide variety of alkyl halides was reported, which led to the atom‐economic synthesis of functionalized 3, 4‐dihydronaphthalen‐1( 2H )‐ones with good yields and high stereoselectivity under the mild and oxidant‐free conditions. The reaction demonstrated remarkable compatibility regarding alkyl halides as bifunctional reagents, such as ethyl 2‐bromo‐2, 2‐difluoroacetate, ethyl 2, 2‐difluoro‐2‐iodoacetate, perfluorobutyl iodide, bromotrichloromethane, and diethyl 2‐bromomalonate, and enabled wide substrate scope, high functional group tolerance, and 100% atom utilization. Abstract :