The interaction between energy intake, physical activity and UCP2 -866G/A gene variation on weight gain and changes in adiposity: an Indonesian Nutrigenetic Cohort (INDOGENIC). Issue 6 (28th March 2021)

• Record Type: Journal Article
• Authors: Muhammad, Harry Freitag Luglio; Sulistyoningrum, Dian Caturini; Huriyati, Emy; Lee, Yi Yi; Muda, Wan Abdul Manan Wan
• Is Part Of: British journal of nutrition. Volume 125:Issue 6(2021)
• Page Start: 611
• Page End: 617
• Publication Date: 2021-03-28
• Subjects: UCP2, -- Obesity, -- Weight gain, -- Adiposity, -- Energy intake, -- Physical activity; Nutrition -- Periodicals; 572.4
• DOI: 10.1017/S0007114520003104
• Languages: English
• ISSNs: 0007-1145

Abstract

Abstract: The present study aimed to investigate an interaction between energy intake, physical activity and UCP2 gene variation on weight gain and adiposity changes in Indonesian adults. This is a prospective cohort study conducted in 323 healthy adults living in the city of Yogyakarta, Indonesia. Energy intake, physical activity, body weight, BMI, percentage body fat and waist:hip ratio (WHR) were measured at baseline and after 2 years while UCP2 -866G/A gene variation was determined at baseline. We reported that after 2 years subjects had a significant increment in body weight, BMI, body fat and reduction in WHR (all P < 0·05). In all subjects, total energy intake was significantly correlated with changes in body weight ( β = 0·128, P = 0·023) and body fat ( β = 0·123, P = 0·030). Among subjects with the GG genotype, changes in energy intake were positively correlated with changes in body weight ( β = 0·232, P = 0·016) and body fat ( β = 0·201, P = 0·034). These correlations were insignificant among those with AA + GA genotypes (all P > 0·05). In summary, we show that UCP2 gene variation might influence the adiposity response towards changes in energy intake. Subjects with the GG genotype of UCP2 -866G/A gene were more responsive to energy intake, thus more prone to weight gain due to overeating.