A hexanuclear Nd (III) complex derived from a Schiff base with significant antitumor and antifungal activity. (30th October 2020)

• Record Type: Journal Article
• Authors: Hua, Lijuan; Li, Wenge; Chen, Yan; Liang, Kai; Cai, He; Wang, Jing; Wang, Siyu; Yin, Tianyue; Liang, Lili
• Is Part Of: Applied organometallic chemistry. Volume 35:Number 2(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-10-30
• Subjects: antifungal activity -- antitumor activity -- Nd (III) complex -- Schiff base -- X‐ray; Organometallic chemistry -- Periodicals; Organometallic compounds -- Periodicals; 547.05
• DOI: 10.1002/aoc.6081
• Languages: English
• ISSNs: 0268-2605

Abstract

Abstract : A hexanuclear Nd (III) complex {[Nd6 (HL)2 L2 X2 (NO3 )8 (EtOH)6 ]·(EtOH)(H2 O)3 } (H2 L = 2, 3‐dihydroxybenzaldehyde‐4‐aminoantipyrine; H2 X = 2, 3‐dihydroxy benzaldehyde) has been designed, synthesized, and evaluated for antitumor and antifungal activity. Single‐crystal X‐ray diffraction analysis indicates Nd (III) complex has a trinuclear cluster structure, which further forms a hexanuclear monomer through two bridging ligands L 2− . There are π–π interactions and a lot of intramolecular hydrogen bonds between monomers. Antitumor activity of Nd (III) complex against human hepatocellular carcinoma SMMC‐7721 cells has been studied by 3‐(4, 5‐dimethyl‐2‐thiazolyl)‐2, 5‐diphenyltetrazolium bromide (MTT) assay and morphology observation. The IC50 value of Nd (III) complex ranges from 4.02 to 4.85 μM, much smaller than that of clinical drug (gemcitabin) and free ligand (H2 L), which is consistent with its high inhibition rate of 90%. Inhibitory zone of 26 mm reveals the significant antifungal activity of Nd (III) complex against Candida albicans . Abstract : A hexanuclear Nd (III) complex has been designed and synthesized. The hexanuclear structure of the complex has been evaluated by X‐ray single‐crystal diffraction analysis. Interestingly, this Nd (III) complex possesses significant antitumor properties against SMMC‐7721 cells and antifungal activity toward Canidia albicans .