Identification of a novel TNRC18‐RARA fusion in acute promyelocytic leukemia lacking t(15;17)(q24;q12)/PML‐RARA. Issue 2 (11th January 2021)

• Record Type: Journal Article
• Authors: Wang, Zheng; Wen, Lijun; Zhang, Ling; Xu, Xiaoyu; Chen, Xiaoqian; Yao, Li; Wang, Man; Shen, Zhen; Mo, Guangquan; Wang, Yao; Zhao, Dewan; Cai, Wei; Shen, Jingzhi; Chi, Xiaomeng; Xu, Yi; Zeng, Zhao; Pan, Jinlan; Ruan, Changgeng; Wu, Depei; Jia, Zhilin; Chen, Suning
• Is Part Of: Molecular carcinogenesis. Volume 60:Issue 2(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-01-11
• Subjects: acute promyelocytic leukemia -- TNRC18 -- RARA -- PML‐RARA; Carcinogenesis -- Molecular aspects -- Periodicals; 616.994071
• DOI: 10.1002/mc.23276
• Languages: English
• ISSNs: 0899-1987

Abstract

Abstract: Acute promyelocytic leukemia (APL) is a unique disease entity in acute myeloid leukemia, characterized by PML‐RARA fusion gene, which is generated by chromosomal translocation t(15;17)(q24;q21). We identified TNRC18‐RARA as novel RARA fusion in resembling APL. Our study highlights the importance of combining multiple molecular techniques to characterize and optimally manage APL lacking classic t(15;17)(q24;q12)/ PML‐RARA fusion.