Gastrointestinal tract metastasis of lung cancer: The PD‐L1 expression and correlated clinicopathological variables. Issue 1 (1st December 2020)

• Record Type: Journal Article
• Authors: Ishikawa, Eri; Nakaguro, Masato; Nakamura, Masanao; Yamamura, Takeshi; Sawada, Tsunaki; Mizutani, Yasuyuki; Maeda, Keiko; Furukawa, Kazuhiro; Shimoyama, Yoshie; Kawashima, Hiroki; Fujishiro, Mitsuhiro
• Is Part Of: Pathology international. Volume 71:Issue 1(2021)
• Page Start: 33
• Page End: 41
• Publication Date: 2020-12-01
• Subjects: gastrointestinal metastasis -- lung cancer -- PD‐L1 -- small bowel -- small‐bowel metastasis; Pathology -- Periodicals; 616.07
• DOI: 10.1111/pin.13048
• Languages: English
• ISSNs: 1320-5463

Abstract

Abstract: The gastrointestinal tract is a rare site for metastatic lung cancer. Programmed cell death‐ligand 1 (PD‐L1) expression in lung cancer is a biomarker for the response to anti‐PD‐1/PD‐L1 therapy. We investigated clinicopathological features and PD‐L1 expression in 25 gastrointestinal metastatic tumors from the lung and primary adenocarcinoma of the small bowel. The small bowel was the most common site (16/25; 64%) of gastrointestinal tract lung cancer metastasis. A total of 19 (76%) of the gastrointestinal metastasis showed PD‐L1 expression in ≥5% of tumor cells, with 14 (56%) showing high expression levels (≥50%). In contrast, 21 (84%) expressed PD‐L1 in ≥5% immune cells, including 4 (16%) showing a high expression levels (≥50%). The PD‐L1 expression on tumor cells and immune cells in primary lung cancer and corresponding gastrointestinal metastasis was concordant in 13 (68%) and 11 (58%) of the 19 paired cases, respectively. Small‐bowel metastasis of lung cancer was characterized by a higher incidence of perforation (31% vs. 0%), ulcerated mass (83% vs. 60%), and neoplastic PD‐L1 expression (75% vs. 0%) compared to primary small‐bowel adenocarcinoma. Gastrointestinal metastasis from lung cancer might be a potential target for immune checkpoint inhibitor therapy, given its high expression of PD‐L1.