How defective spermatogenesis affects sperm DNA integrity. (23rd April 2020)

• Record Type: Journal Article
• Authors: Kuchakulla, Manish; Narasimman, Manish; Khodamoradi, Kajal; Khosravizadeh, Zahra; Ramasamy, Ranjith
• Other Names: Agarwal Ashok guestEditor.; Baskaran Saradha guestEditor.; Durairajanayagam Damayanthi guestEditor.; Ramasamy Ranjith guestEditor.; Ko Edmund guestEditor.
• Is Part Of: Andrologia. Volume 53:Number 1(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-04-23
• Subjects: chromatin remodelling -- sperm DNA damage -- sperm DNA repair mechanisms -- spermatogenesis -- spermatogenesis regulation; Andrology -- Periodicals; Infertility, Male -- Periodicals; 616.69
• DOI: 10.1111/and.13615
• Languages: English
• ISSNs: 0303-4569

Abstract

Abstract: Spermatogenesis is the essential process to maintain and promote male fertility. It is extraordinarily complex with many regulatory elements and numerous steps. The process involves several cell types, regulatory molecules, repair mechanisms and epigenetic regulators. Evidence has shown that fertility can be negatively impacted by reduced sperm DNA integrity. Sources of sperm DNA damage include replication errors and causes of DNA fragmentation which include abortive apoptosis, defective maturation and oxidative stress. This review outlines the process of spermatogenesis, spermatogonial regulation and sperm differentiation; additionally, DNA damage and currently studied DNA repair mechanisms in spermatozoon are also covered.