Origin of the MRI Contrast in Natural and Hydrogel Formulation of Pineapple Juice. (5th January 2021)
- Record Type:
- Journal Article
- Title:
- Origin of the MRI Contrast in Natural and Hydrogel Formulation of Pineapple Juice. (5th January 2021)
- Main Title:
- Origin of the MRI Contrast in Natural and Hydrogel Formulation of Pineapple Juice
- Authors:
- Rizzo, Domenico
Ravera, Enrico
Fragai, Marco
Parigi, Giacomo
Luchinat, Claudio - Other Names:
- Osella Domenico Academic Editor.
- Abstract:
- Abstract : Magnetic resonance imaging (MRI) often requires contrast agents to improve the visualization in some tissues and organs, including the gastrointestinal tract. In this latter case, instead of intravascular administration, oral agents can be used. Natural oral contrast agents, such as fruit juice, have the advantages of better taste, tolerability, and lower price with respect to the artificial agents. We have characterized the relaxometry profiles of pineapple juice in order to understand the origin of the increase in relaxation rates (and thus of the MRI contrast) in reference to its content of manganese ions. Furthermore, we have characterized the relaxometry profiles of pineapple juice in the presence of alginate in different amounts; the interaction of the manganese ions with alginate slows down their reorientation time to some extent, with a subsequent increase in the relaxation rates. The relaxometry profiles were also compared with those of manganese(II) solutions in 50 mmol/dm 3 sodium acetate solution (same pH of pineapple juice), which revealed sizable differences, mostly in the number of water molecules coordinated to the metal ion, their lifetimes, and in the constant of the Fermi-contact interaction. Finally, the fit of the transverse relaxivity shows that the increased viscosity in the hydrogel formulations can improve significantly the negative contrast of pineapple juice at the magnetic fields relevant for clinical MRI.
- Is Part Of:
- Bioinorganic chemistry and applications. Volume 2021(2021)
- Journal:
- Bioinorganic chemistry and applications
- Issue:
- Volume 2021(2021)
- Issue Display:
- Volume 2021, Issue 2021 (2021)
- Year:
- 2021
- Volume:
- 2021
- Issue:
- 2021
- Issue Sort Value:
- 2021-2021-2021-0000
- Page Start:
- Page End:
- Publication Date:
- 2021-01-05
- Subjects:
- Bioinorganic chemistry -- Periodicals
Bioinorganic chemistry
Biochemistry
Inorganic Chemistry
Chemistry, Bioinorganic
Periodicals
572.51 - Journal URLs:
- https://www.hindawi.com/journals/bca/ ↗
http://www.pubmedcentral.nih.gov/tocrender.fcgi?journal=419&action=archive ↗ - DOI:
- 10.1155/2021/6666018 ↗
- Languages:
- English
- ISSNs:
- 1565-3633
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library HMNTS - ELD Digital store
- Ingest File:
- 15566.xml