Outcomes after Surgery for Early Stage Breast Cancer in Women Staged With Preoperative Breast Magnetic Resonance Imaging According to Breast Tissue Density. Issue 2 (4th June 2019)

• Record Type: Journal Article
• Authors: Faermann, Renata; Weidenfeld, Jonathan; Chepelev, Leonid; Kendal, Wayne; Verma, Raman; Scott-Moncrieff, Andrew; Peddle, Susan; Doherty, Geoff; Lau, Jackie; Ramsay, Tim; Arnaout, Angel; Lamb, Leslie; Watters, James M; Seely, Jean M
• Is Part Of: Journal of breast imaging. Volume 1:Issue 2(2019)
• Page Start: 115
• Page End: 121
• Publication Date: 2019-06-04
• Subjects: breast cancer -- breast tissue density -- survival -- outcome -- breast MRI; Breast -- Imaging -- Periodicals; Breast -- Cancer -- Diagnosis -- Periodicals; 616.994490
• DOI: 10.1093/jbi/wbz018
• Languages: English
• ISSNs: 2631-6110

Abstract

Abstract: Purpose: To determine surgical outcomes and breast cancer disease-free survival outcomes of women with early stage breast cancer with and without use of preoperative breast MRI according to breast tissue density. Methods: Women with early stage breast cancer diagnosed from 2004 to 2009 were classified into 2 groups: 1) those with dense and heterogeneously dense breasts (DB); 2) those with nondense breasts (NDB) (scattered fibroglandular and fatty replaced tissue). The 2 groups were reviewed to determine who underwent preoperative MRI. Breast tissue density was determined with mammography according to ACR BI-RADS. Patients were compared according to tumor size, grade, stage, and treatment. Survival analysis was performed using Kaplan-Meier estimates. Results: In total, 261 patients with mean follow-up of 85 months (25–133) were included: 156 DB and 105 NDB. Disease-free survival outcomes were better in the DB group in patients with MRI than in those without MRI: patients with MRI had significantly fewer local recurrences ( P < 0.016) and metachronous contralateral breast cancers ( P < 0.001), but this was not the case in the NDB group. Mastectomies were higher in the DB group with preoperative MRI than in those without MRI ( P < 0.01), as it was in the NDB group ( P > 0.05). Conclusions: Preoperative breast MRI was associated with reduced local recurrence and metachronous contralateral cancers in the DB group, but not in the NDB group; however, the DB patients with MRI had higher mastectomy rates.