Results of large pulmonary homograft implantation for right ventricular outflow tract reconstruction. Issue 2 (15th December 2020)

• Record Type: Journal Article
• Authors: Dang Van, Simon; Pavy, Carine; Guimbretière, Guillaume; Boulanger, Julie; Maminirina, Pierre; Guerin, Patrice; Baron, Olivier
• Is Part Of: Journal of cardiac surgery. Volume 36:Issue 2(2021)
• Page Start: 442
• Page End: 448
• Publication Date: 2020-12-15
• Subjects: congenital heart disease -- pulmonary homograft -- reoperation -- right ventricular outflow tract; Heart -- Surgery -- Periodicals; 617.412005
• DOI: 10.1111/jocs.15184
• Languages: English
• ISSNs: 0886-0440

Abstract

Abstract: Background: To evaluate the long‐term results of implantation of homogeneous large size of pulmonary homograft (PH) for reconstruction of the right ventricular outflow tract (RVOT). Methods: Between January 2000 and December 2017, 107 patients were implanted with PH for reconstruction of the RVOT. Data were collected retrospectively in this single‐center study. PH failure was defined as a peak of gradient greater than 40 mmHg and/or as a pulmonary regurgitation greater than Grade 2. Primary endpoint was the reoperation of the RVOT during follow‐up. Secondary endpoints were overall survival, occurrence of PH failure and the rate of reoperation for all cause. Results: Mean age of the recipients was 26.1 ± 13.6 years. Median follow‐up interval was 2.99 years (interquartile range [IQR]: 6.2). Mean size of PH was 24.9 ± 1.9 mm. Reoperation of the RVOT occurred in eight patients (7.8%). Time before reoperation was 2.74 years (IQR: 6.4). Freedom from reoperation for RVOT at 5 and 10 years was respectively 95.7% and 90.0%. Overall survival at 10 years was 95.2%. PH failure occurred in 13 patients (12.0%). Median time before PH failure was 6.7 years (IQR: 9.6). Freedom from PH failure at 10 years was 81.6%. Reoperation for PH failure occurred in four patients (3.9%). Concomitant tricuspid surgery ( p = .01; 95% confidence interval [CI]: 1.9–319.6) and undersized PH ( p = .01; 95% CI: 2.06–719.8) were independent risk factors of late reoperation. Conclusion: Implantation of large PH for RVOT reconstruction provides excellent midterm results in terms of reoperation.