Assessment of oro-dental manifestations in a series of acromegalic patients, the AcroDent study. Issue 8 (August 2020)

• Record Type: Journal Article
• Authors: Roumeau, Sylvain; Thevenon, Joannice; Ouchchane, Lemlih; Maqdasy, Salwan; Batisse-Lignier, Marie; Duale, Christian; Pham Dang, Nathalie; Caron, Philippe; Tauveron, Igor; Devoize, Laurent
• Is Part Of: Endocrine connections. Volume 9:Issue 8(2020)
• Page Start: 824
• Page End: 833
• Publication Date: 2020-08
• Subjects: acromegaly -- growth hormone-secreting pituitary adenoma -- oral manifestations -- periodontal diseases -- quality of life; Endocrinology -- Periodicals; 616.4005
• DOI: 10.1530/EC-20-0176
• Languages: English
• ISSNs: 2049-3614

Abstract

Abstract : Objective: : The dental and periodontal impact of GH/IGF-1 hypersecretion has been poorly investigated until now. Our aim is to precisely describe the oro-dental state of acromegalic patients and to study the impact of GH/IGF-1 hypersecretion on patients' reported oral health-related quality of life (OHRQoL). Methods: : After collecting characteristics of their disease, acromegalic patients answered the GOHAI questionnaire assessing their OHRQoL, the AcroQoL questionnaire and then benefited from a complete stomatological and radiological examination (orthopantomogram systematically, retro-alveolar radiography or Cone Beam CT if necessary). Results: : In total, 29 patients aged 59.1 ± 16.0 years were included. The average DMFT index (sum of Decayed, Missing and Filled Teeth per patient) was 19.0 ± 7.8. 16/29 patients had a gingivitis and 18/29 a mild to moderate chronic periodontitis, but no case of severe chronic periodontitis was found, probably because the frequency of a protective thick gingival biotype was increased (9/29). No case of generalized gingival hypertrophy or diffuse hypercementosis was observed. According to the Add-GOHAI score, only 8/26 patients had a satisfactory OHRQoL. This parameter was correlated to the acromegaly-specific quality of life according to the AcroQoL score. Interestingly, 11/29 patients had bulky oral bony outgrowths (OBO), such as large maxillary or mandibular tori and multiple vestibular exostosis. Conclusions: : The unsatisfactory OHRQoL reported by acromegalic patients contrasts with a rather good objective oro-dental state and annual oral examination seems relevant in this population. Finally, we report that huge OBO could be helpful signposts for the diagnosis of acromegaly.