CoCoCoNet: conserved and comparative co-expression across a diverse set of species. Issue Volume 48:Issue W1(2020) (11th May 2020)
- Record Type:
- Journal Article
- Title:
- CoCoCoNet: conserved and comparative co-expression across a diverse set of species. Issue Volume 48:Issue W1(2020) (11th May 2020)
- Main Title:
- CoCoCoNet: conserved and comparative co-expression across a diverse set of species
- Authors:
- Lee, John
Shah, Manthan
Ballouz, Sara
Crow, Megan
Gillis, Jesse - Abstract:
- Abstract: Co-expression analysis has provided insight into gene function in organisms from Arabidopsis to zebrafish. Comparison across species has the potential to enrich these results, for example by prioritizing among candidate human disease genes based on their network properties or by finding alternative model systems where their co-expression is conserved. Here, we present CoCoCoNet as a tool for identifying conserved gene modules and comparing co-expression networks. CoCoCoNet is a resource for both data and methods, providing gold standard networks and sophisticated tools for on-the-fly comparative analyses across 14 species. We show how CoCoCoNet can be used in two use cases. In the first, we demonstrate deep conservation of a nucleolus gene module across very divergent organisms, and in the second, we show how the heterogeneity of autism mechanisms in humans can be broken down by functional groups and translated to model organisms. CoCoCoNet is free to use and available to all at https://milton.cshl.edu/CoCoCoNet, with data and R scripts available at ftp://milton.cshl.edu/data .
- Is Part Of:
- Nucleic acids research. Volume 48:Issue W1(2020)
- Journal:
- Nucleic acids research
- Issue:
- Volume 48:Issue W1(2020)
- Issue Display:
- Volume 48, Issue 1 (2020)
- Year:
- 2020
- Volume:
- 48
- Issue:
- 1
- Issue Sort Value:
- 2020-0048-0001-0000
- Page Start:
- W566
- Page End:
- W571
- Publication Date:
- 2020-05-11
- Subjects:
- Nucleic acids -- Periodicals
Molecular biology -- Periodicals
572.805 - Journal URLs:
- http://nar.oxfordjournals.org/ ↗
http://www.ncbi.nlm.nih.gov/pmc/journals/4 ↗
http://ukcatalogue.oup.com/ ↗
http://firstsearch.oclc.org ↗ - DOI:
- 10.1093/nar/gkaa348 ↗
- Languages:
- English
- ISSNs:
- 0305-1048
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 6183.850000
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 15549.xml